Diagnostic Criteria of Autoimmune Diseases

According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA-up to eight percent of the population-are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Diagnostic Criteria in Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

CONTENTS

I. CLASSICAL SYSTEMIC AUTOIMMUNE DISEASES

 

1. Systemic Lupus Erythematosus:

Maria Laura Bertolaccini

Lupus Research Unit

The Rayne Institute

King's College London School of Medicine

St. Thomas' Hospital

London

UK

 

Graham RV Hughes

Lupus Research Unit

The Rayne Institute

King's College London School of Medicine

St. Thomas' Hospital

London

UK

 

Munther A. Khamashta, MD

Senior Lecturer/Consultant Physician

Lupus Unit

The Rayne Institute

St. Thomas Hospital

London

UK

 

2. Antiphospholipid Syndrome:

Ricard Cervera, MD, PhD, FRCP

Head, Department of Autoimmune Diseases, Hospital ClÉnic

Associate Professor, Department of Medicine

University of Barcelona

Catalonia, Spain

 

Ronald A. Asherson

Division of Immunology

School of Pathology

University of the Witwatersrand

Johannesburg, South Africa

 

3. Rheumatoid Arthritis:

Claudio Galarza-Maldonado, MD

Unidad de Enfermedades Reumaticas y Autoinmunes (UNERA)

Hospital Monte SinaÉ

Cuenca, Ecuador

 

Loreto Massardo Vega, M.D.2

Departamento de ImmunologÉa ClÉnica y ReumatologÉa

Facultad de Medicina

Pontificia Universidad Catolica de Chile

Santiago

Chile

 

Bernardo Pons-Estel, M.D. 3

Hospital provincial de Rosario

Universidad Nacional de Rosario

Rosario Argentina

 

Mario H. Cardiel, MSc

Unidad de Investigación "Dr. Mario Alvizouri Muño"

Hospital General "Dr. Miguel Silva

Morelia

Michoacán

Mexico

 

 

4. Macrophage Activation Sindrome in Juvenile Idiopathic Arthritis:

Berkun Yackov, M.D.

Associate Director

Pediatric Rheumatology

Safra Children Hospital

Chaim Sheba Medical Center

Tel-Hashomer

Israel

and

Sackler School of Medicine

Tel-Aviv University

Tel-Aviv

Israel

 

Shai Padeh, M.D.

Pediatric Rheumatology

Safra Children Hospital

Chaim Sheba Medical Center

Tel-Hashomer

Israel

and

Sackler School of Medicine

Tel-Aviv University

Tel-Aviv

Israel

 

5. Adult Still's Disease:

Alon Eisen, M.D.

Department of Medicine D

Meir Medical Center

Kfar-Saba

Israel

Affiliated to Sackler Faculty of Medicine

Tel-Aviv University Tel-Aviv

Israel

 

Howard Amital, MD MHA

Head of Department of Medicine D

Meir Medical Center

Kfar-Saba

Israel

Affiliated to Sackler Faculty of Medicine

Tel-Aviv University Tel-Aviv

Israel

 

6. Systemic Sclerosis:

Dr. Jenny Walker

Faculty of Medicine

University of Calgary

Calgary, Alberta, Canada

 

Marvin J. Fritzler, MD, PhD

Faculty of Medicine

University of Calgary

Calgary, Alberta, Canada

 

7. Sjögren's Syndrome:

D. Mitsias

Department of Pathophysiology

School of Medicine

National University of Athens

Athens

Greece

 

H.M.Moutsopoulos, MD, FACP,FRCP

Professor and Director

Department of Pathophysiology

School of Medicine

National University of Athens

Athens

Greece

 

8. Mixed Connective Tissue Diseases (MCTD):

Marta Mosca, M.D.

Rheumatology Unit

Department of Internal Medicine

University of Pisa

Italy

 

Rosaria Talarico, M.D.

Rheumatology Unit

Department of Internal Medicine

University of Pisa

Italy

 

Stefano Bombardieri

Rheumatology Unit

Department of Internal Medicine

University of Pisa

Italy

 

9. Relapsing Polychodritis

Mauro Galeazzi

Unità Operativa Complessa di Rheumatologia

University of Siena

Siena

 

Giovanni Porciello

Unità Operativa Medicina Interna

Ospedale Misericordia e Dolce

Prato

 

10. Raynaud's Phenomenon:

Mario Garcia-Carrasco, M.D., PhD

Systemic Autoimmune Diseases Research Unit

HGR #36

CMN Manuel Ávila Camacho

IMSS

Puebla, México and

Rheumatology Department

Benemerita Universidad Autonoma de Puebla

School of Medicine. Puebla, México.

 

Mario Jiménez-Hernandez, M.D.

Systemic Autoimmune Diseases Research Unit

HGR #36

CMN Manuel Ávila Camacho

IMSS

Puebla, México

 

Ricardo O. Escárcega, M.D.

Internal Medicine

Temple University Hospital Philadelphia

Philadelphia

PA

 

Ivet Etchegaray-Morales, M.D.

Systemic Autoimmune Diseases Research Unit

HGR #36

CMN Manuel Ávila Camacho

IMSS

Puebla, México

 

Juan Carlos Pérez-Alva, M.D.

Cardiovascular Institut.

Hospital Angeles

Puebla

Mexico

 

11. Drug-induced Autoimmunity:

Martine Szyper-Kravitz, MD

Center for Autoimmune Diseases and

Department of Medicine B

Chaim Sheba Medical Center Tel-Hashomer

Sackler Faculty of Medicine

Tel Aviv University

Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Head, Department of Medicine B

Center for Autoimmune Diseases

Sheba Medical Center

Tel-Hashomer

Israel

 

12. The Multiple Autoimmune Syndromes:

Juan-Manuel Anaya, MD

Professor of Medicine

Cellular Biology and Immunogenetics Unit

Corporation for Biological Research

MedellÉn-Colombia

And

Universidad del Rosario

Bogotá

Columbia

 

John Castiblanco

Cellular Biology and Immunogenetics Unit

Corporation for Biological Research

MedellÉn-Colombia

 

Adriana Rojas-Villarraga

Cellular Biology and Immunogenetics Unit

Corporation for Biological Research

MedellÉn-Colombia

And

Universidad del Rosario

Bogotá

Columbia

 

II. SYSTEMIC VASCULITIS

 

13. Giant Cell Arteritis:

Gideon Nesher, M.D.

Director

Department of Internal Medicine A and

The Rheumatology Service

Shaare-Zedek Medical Center

Jerusalem

Israel

 

14. Takayasu Arteritis:

Rosa Maria Rodrigues Pereira, M.D., PhD

Rheumatology Division

University of São Paulo

School of Medicine

São Paulo

Brazil

 

Jozélio Freire De Carvalho, MD, PhD

Assistant Professor

Faculdade de Medicina e Hospital das ClÉnicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo -SP

Brazil

 

MaurÉcio Levy-Neto, M.D., PhD

Rheumatology Division

University of São Paulo

School of Medicine

São Paulo

Brazil

 

EloÉsa Bonfá

Rheumatology Division

University of São Paulo

School of Medicine

São Paulo

Brazil

 

15. Polyarteritis Nodosa:

José Hernández-RodrÉguez, M.D.

Vasculitis Research Unit

Department of Systemic Autoimmune Diseases

Institute of Medicine and Dermatology

Hospital Clinic

University of Barcelona

Institut d'Investigacions

Biomèdiques August Pi i Sunyer (IDIBAPS)

Barcelona

Spain

 

Maria C. Cid, MD

Consultant, Assistant Professor, Senior Investigator

Department of Internal Medicine

Vasculitis Research Unit

Department of Systemic Autoimmune Diseases

Institute of Medicine and Dermatology

Hospital Clinic

University of Barcelona

Institut d'Investigacions

Biomèdiques August Pi i Sunyer (IDIBAPS)

Barcelona

Spain

 

16. Microscopic Polyangiitis:

C.G.M. Kallenberg, MD, PhD

Professor of Medicine

Head Department of Clinical Immunology

University Medical Center Groningen

University of Groningen

Groningen,The Netherlands

 

17. Wegener's Granulomatosis:

Julia U. Holle. M.D.

Department of Rheumatology

University Hospital Schleswig-Holstein

Campus Lübeck

Lübeck Germany

 

Elena Csernok

Department of Rheumatology

University Hospital Schleswig-Holstein

Campus Lübeck

Lübeck Germany

 

Wolfgang L. Gross

Department of Rheumatology

University Hospital Schleswig-Holstein

Campus Lübeck

Lübeck Germany

 

18. Churg-Strauss Syndrome:

Philippe Guilpain, M.D.

Department of Internal Medicine and

Referral Center for Necrotizing Vasculitides and Systemic Sclerosis

University Paris 5 - René Descartes

Cochin Hospital

Paris

France

and

Systemic Diseases Study Group

University Paris 5 - René Descartes

Paris

France

 

Loïc Guilleven

Department of Internal Medicine and

Referral Center for Necrotizing Vasculitides and Systemic Sclerosis

University Paris 5 - René Descartes

Cochin Hospital

Paris

France

and

Systemic Diseases Study Group

University Paris 5 - René Descartes

Paris

France

 

19. Buerger's Disease:

Michael Ehrenfeld, M.D.

Clinical Associate Professor

Dept. of Medicine C and the Rheumatic Disease Unit and

the department of Vascular Surgery

Chaim Sheba Medical Center

Tel-Hashomer

Israel

and

the Tel-Aviv University

Tel-Aviv

Israel

 

Raphael Adar

Dept. of Medicine C and the Rheumatic Disease Unit and

the department of Vascular Surgery

Chaim Sheba Medical Center

Tel-Hashomer

Israel

and

the Tel-Aviv University

Tel-Aviv

Israel

 

20. Behçet's Disease:

Dr. Gerard Espinosa MD PhD

Department of Autoimmune Diseases

Hospital ClÉnic

Barcelona, Catalonia, Spain

 

21. Susac Syndrome:

Manuel Francisco Ugarte, M.D.

Faculty of Medicine

Universidad Nacional Mayor de San Marcos

And

Department of Rheumatology

Hospital Almenara

Lima

Peru

 

Ricard Cervera, M.D., PhD, FRCP

Department of Autoimmune Diseases

Hospital Clinic

Barcelona

Catalonia

Spain

 

22. Goodpasture's Disease:

Thomas Hellmark, PhD

Associate Professor

Department of Clinical Sciences in Lund

Lund University

Sweden

 

Mårten Segelmark

Department of Nephrology

Clinical Sciences in Lund

Lund University

Sweden

 

23. Kawasaki Disease:

Jordi Anton, MD

Associate Professor

Pediatric Rheumatology Unit

Hospital Sant Joan de Déu

University of Barcelona

Barcelona

Spain

 

Rosa Bou, MD

Pediatric Rheumatology Unit

Hospital Parc Tauli, Sabadell

Barcelona

Spain

 

24. Cogan's Syndrome:

Aharon Kessel, M.D.

Allergy and Clinical Immunology

Bnai-Zion Medical Center

The Bruce Rappaport Faculty of Medicine

Technion Medical School

Haifa

Israel

 

Elias Toubi, M.D.

Director of Clinical Immunology and Allergy

Bnai-Zion Medical Center,

The Bruce Rappaport Faculty of Medicine

Technion Medical School

Haifa

Israel

 

25. Henöch-Schönlein Purpura:

Margalit Lorber

Autoimmune Disease Unit

Division of Medicine

Rambam Health Campus

The Rappaport Faculty of Medicine

Technion

Haifa

Israel

 

26. Cryoglobulinemic Syndrome:

Suk Seo, M.D.

Pfleger Liver Institute

David Geffen School of Medicine at UCLA

Los Angeles, CA

 

Natalie J. Torok, M.D.

Assistant Professor

Division of Gastroenterology and Hepatology

University of California Davis Medical Center

Sacramento

California

 

27. Hypersensitivity Angiitis:

Shimon Pollack, MD

Associate Professor of Medicine & Immunology

Rappaport Faculty of Medicine - Technion, Israel Institute of Technology

Director , Institute for Allergy , Immunology & AIDS

Rambam Medical Center

Haifa

Israel

 

III. IDIOPATHIC INFLAMMATORY MYOPATHIES

 

28. Polymyositis:

Georgina EspÉgol, M.D.

Internal Medicine Department

Medicine and Dermatology Institute

Hospital Clinic of Barcelona

University of Barcelona

Barcelona

Spain

 

Josep M. Grau, MD, PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

Professor of Medicine

University of Barcelona

Barcelona, Catalonia, Spain

 

29. Dermatomyositis:

Prof. Andrea Doria

Division of Rheumatology

University of Padova

Padova

Italy

 

Chiara Briani

Department of Neurosciences

University of Padova

Padova

Italy

 

Anna Ghirardello

Division of Rheumatology

University of Padova

Padova

Italy

 

Sandra Zampieri

Division of Rheumatology

University of Padova

Padova

Italy

 

Piercarlo Sarzi-Puttini

Department of Rheumatology

Rheumatology Unit

L Sacco University Hospital

Milan

Italy

 

Ricardo Rondinone

Division of Rheumatology

University of Padova

Padova

Italy

 

30. Sporadic Inclusion Body Myositis (sIBM):

Josep M. Grau, MD, PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

Professor of Medicine

University of Barcelona

Barcelona, Catalonia, Spain

 

Albert Selva-O'Callaghan, M.D., PhD

Internal Medicine Department

Hospital Vall d'Hebrón

Universitat Autónoma de Barcelona

Barcelona

Spain

 

31. Antisynthetase Syndrome:

Ira N. Targoff, M.D.

Professor of Medicine

Department of Medicine

University of Oklahoma Health Sciences Center

Veterans Affairs Medical Center

Oklahoma Medical Research Foundation

Oklahoma City

Oklahoma

 

32. Granulomatous Myositis:

Sergio Prieto, M.D.

Internal Medicine Department

Medicine and Dermatology Institute

Hospital ClÉnic de Barcelona

University of Barcelona

Barcelona

Spain

 

Josep M. Grau, M.D., PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

University of Barcelona

Barcelona, Catalonia, Spain

 

33. Eosinophilic Myositis:

Albert Selva-O'Callaghan, M.D., PhD

Internal Medicine Department

Hospital Vall d'Hebrón

Universitat Autónoma de Barcelona

Barcelona

Spain

 

Josep M. Grau, MD, PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

Professor of Medicine

University of Barcelona

Barcelona, Catalonia, Spain

 

34. Eosinophilic Fasciitis:

Albert Selva-O'Callaghan, M.D., PhD

Internal Medicine Department

Hospital Vall d'Hebrón

Universitat Autónoma de Barcelona

Barcelona

Spain

 

Josep M. Grau, MD, PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

Professor of Medicine

University of Barcelona

Barcelona, Catalonia, Spain

 

IV. OTHER IMMUNE-MEDIATED SYSTEMIC DISEASES

 

35. Sarcoidosis:

Juan Mañá, MD

Associate Professor of Medicine

Department of Internal Medicine

Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)

Bellvitge University Hospital

University of Barcelona

Barcelona

Spain

 

36. Spondyloarthropathies:

Michael Ehrenfeld, M.D.

Clinical Associate Professor

Dept. of Medicine C and the Rheumatic Disease Unit and

the department of Vascular Surgery

Chaim Sheba Medical Center

Tel-Hashomer

Israel

and

the Tel-Aviv University

Tel-Aviv

Israel

 

37. Periodic Fever Syndromes:

Shai Padeh, M.D.

Safra Children Hospital

Sheba Medical Center

Tel-Hashomer

Israel

 

Yackov Berkun , M.D.

Lecturer, Sackler Faculty of Medicine, Tel-Aviv University

Rheumatology and Immunology Clinic

Associate Director of Safra Childrens Hospital

Sheba Medical Center

Tel-Hashomer 52621

ISRAEL

 

38. The Fibromyalgia Syndrome:

Y. Arnson

Department of Medicine D

Meir Medical Center

Kfar-Saba, Israel

Affiliated to the Sackler Faculty of Medicine

Tel-Aviv University

Tel-Aviv, Israel

 

Z. Dvorish

Department of Medicine D

Meir Medical Center

Kfar-Saba, Israel

Affiliated to the Sackler Faculty of Medicine

Tel-Aviv University

Tel-Aviv, Israel

 

D. Amital

Department of Psychiatry B

Ness-Ziona Mental Health Center

Ness-Ziona

 

H Amital, M.D.

Head of Department of Medicine D

Meir Medical Center

Kfar-Saba, Israel

 

B. ORGAN-SPECIFIC AUTOIMMUNE DISEASES

 

V. ENDOCRINE AND REPRODUCTIVE AUTOIMMUNE DISEASES

 

39. Hashimoto's Thyroiditis: Clinical and Diagnostics Criteria:

R. Rocchi

Institute of Endocrinology

University of Pisa

Italy

 

N.R. Rose, MD, PhD

Professor of Pathology

Professor of Molecular Microbiology and Immunology

Director, Johns Hopkins Center for Autoimmune Disease Research

Bloomberg School of Public Health

Baltimore

Maryland

 

P. Caturegli

Departments of Pathology and

Molecular Microbiology and Immunology

The Hohns Hopkins University

Baltimore

Maryland

 

40. Atrophic Thyroiditis:

Luis J. Jara, M.D.

Direction of Education and Research

Hospital de Especialidades

Centro Médico

La Raza

Instituto Mexicano del Seguro Social

Mexico City, Mexico

 

Olga Vera-Lastra, M.D.

Internal Medicine Department

Hospital de Especialidades

Centro Médico

La Raza

Instituto Mexicano del Seguro Social

Mexico City, Mexico

 

Gabriela Medina, M.D., MSC

Clinical Research Unit

Hospital de Especialidades

Centro Médico

La Raza

Instituto Mexicano del Seguro Social

Mexico City, Mexico

 

41. Subacute Thyroiditis:

Yemil Atisha-Fregoso, M.D.

Department of Internal Medicine

Instituto Nacional de Cienias Medicas y Nutricion

Salvador Zubiran

Mexico

 

Mario Garcia-Carrasco, M.D.

Systemic Autoimmune Diseases Research Unit

IMSS Puebla

Mexico

 

42. Graves' Disease:

Francesca Menconi, M.D.

Division of Endocrinology

University of Cincinnati College of Medicine

Cincinnati

Ohio

 

Yael L. Oppenheim, M.D.

Endocrinology and Diabetes Associates of Long Island

Rockville Center

NY

 

Yaron Tomer, MD, FACP

Professor of Medicine

Division of Endocrinology

University of Cincinnati College of Medicine

Cincinnati

Ohio

and

Cincinnati VA Medical Center

Cincinnati

Ohio

 

43. Postpartum Thyroiditis:

Alex Stagnaro-Green, MD, MHPE

Senior Associate Dean for Academic Affairs

Touro University College of Medicine

Hackensack

New Jersey

 

44. Diabetes Mellitus Type IA:

Felicia A. Hanzu, M.D.

Diabetes and Obesità Laboratory

Institut d'Investigaciones Biomediques August Pi I Sunyer (IDIBAPS)

University of Barcelona

Barcelona

Spain

 

Ramon Gomis, M.D., PhD

Department of Endocrinology

Hospital ClÉnic

Barcelona, Catalonia, Spain

 

45. Autoimmune Addison's Disease or Autoimmune Adrenalitis:

Jozélio Freire De Carvalho, MD, PhD

Assistant Professor

Faculdade de Medicina e Hospital das ClÉnicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo -SP

Brazil

 

Rodrigo Antonio Brandão Neto, M.D.

Emergency Department of São Paulo University

School of Medicine

São Oaulo-SP

Brazil

 

46. Autoimmune Hypophysitis:

Daria La Torre, M.D.

Department of Internal Medicine

Section of Internal Medicine and Endocrine and Metabolic Sciences

University of Perugia

Perugia

Italy

 

Alberto Falorni, M.D., PhD

Department of Internal Medicine

Section of Internal Medicine and Endocrine and Metabolic Sciences

University of Perugia

Perugia

Italy

 

Elena Bartoloni Bocci

Department of Clinical and Experimental Medicine

Rheumatology Unit

University of Perugia

Perugia

Italy

 

Roberto Gerli, M.D.

Rheumatology Unit

Dept. of Clinical & Experimental Medicine

University of Perugia

Perugia

Italy

 

47. Autoimmune Parathyroid Disease:

Corrado Betterle, M.D.

Chair of Clinical Immunologo

Endocrine Unit

Department of Medical and Surgical Sciences

University of Padova

Padova

Italy

 

48. Autoimmune Polyendocrine Syndromes (APS):

 

A. Tincani

Rheumatology and Clinical Immunology

University and Spedali Civili of Brescia

Italy

 

A. Ceribelli

Rheumatology and Clinical Immunology

University and Spedali Civili of Brescia

Italy

 

I. Cavazzana

Rheumatology and Clinical Immunology

University and Spedali Civili of Brescia

Italy

 

F. Franceschini

Rheumatology and Clinical Immunology

University and Spedali Civili of Brescia

Italy

 

A. Sulli

Research Laboratory and Clinical Academic Unit of Rheumatology

Department of Internal Medicine

University of Genova

Italy

 

M. Cutolo

Research Laboratory and Clinical Academic Unit of Rheumatology

Department of Internal Medicine

University of Genova

Italy

 

49. Endometriosis:

Maurizio Cutolo, M.D.

Research Laboratory and Clinical Academic Unit of Rheumatology

Department of Internal Medicine

University of Genova

Italy

 

Simone Ferrero, M.D.

Department of Obstetrics and Gynecology

San Martino Hospital and

University of Genoa

Italy

 

50. Autoimmune Ovarian Failure:

Francisco Carmona

Head of the Service of Gynaecology.

Hospital ClÉnic

Barcelona, Catalonia, Spain

 

51. Autoimmune Orchitis:

Clovis Artur A. Silva, M.D., PhD

Pediatric Rheumatology Unit

Department of Pediatric

University of Sao Paulo

Brazil

 

Eduardo Ferreira Borba, M.D., PhD

Division of Rheumatology

University of Sao Paulo

São Paulo

Brazil

 

Marcello Cocuzza, M.D.

Department of Urology

University of Sao Paulo

Sao Paulo

Brazil

 

Jozélio Freire De Carvalho, MD, PhD

Assistant Professor

Faculdade de Medicina e Hospital das ClÉnicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo -SP

Brazil

 

EloÉsa Bonfá, M.D., PhD

Division of Rheumatology

University of Sao Paulo

São Paulo

Brazil

 

VI. HEPATOBILIARY AND PANCREATIC AUTOIMMUNE DISEASES

 

52. Autoimmune Hepatitis:

Miquel Bruguera, M.D.

Liver Unit

Hospital ClÉnic

University of Barcelona

Barcelona

Spain

 

53. Primary Biliary Cirrhosis:

Carlo Selmi, M.D., PhD

Division of Rheumatology, Allergy and Clinical Immunology

University of California at Davis

Davis, CA

And

Division of Internal Medicine

Department of Clinical Sciences ‘Luigi Sacco'

University of Milan

Milan, Italy

 

M. Eric Gershwin, M.D.

Division of Rheumatology, Allergy and Clinical Immunology

University of California at Davis

Davis, CA

 

54. Primary Sclerosing Cholangitis:

Sharonjeet Sangha, MD

Department of Internal Medicine

University of California at Davis Medical Center

Sacramento, California

 

Christopher L. Bowlus, M.D.

Division of Gastroenterology and Hepatology

University of California at Davis Medical Center

Sacramento, California

 

55. Extrahepatic Manifestations In Patients With Chronic Hepatitis C Virus Infection:

Pilar Brito-Zerón

Laboratory of Autoimmune Diseases "Josep Font", IDIBAPS

Department of Autoimmune Diseases

School of Medicine

University of Barcelona

Hospital Clinic

Barcelona, Catalonia, Spain

 

Albert Bové

Laboratory of Autoimmune Diseases "Josep Font", IDIBAPS

Department of Autoimmune Diseases

School of Medicine

University of Barcelona

Hospital Clinic

Barcelona, Catalonia, Spain

 

Manuel Ramos-Casals MD, PhD

Department of Autoimmune Diseases

Hospital ClÉnic

Barcelona, Catalonia, Spain

 

56. Autoimmune Pancreatitis:

Salvador Navarro, M.D., PhD

Department of Gastroenterology

Institut Clinic de Malalties Digestives i Metabòliques

Hospital ClÉnic

Barcelona

Catatonia

Spain

 

Francesc Balaguer, M.D.

Specialist

Department of Gastroenterology

Institut Clinic de Malalties Digestives i Metabòliques

Hospital ClÉnic

Barcelona

Catatonia

Spain

 

VII. GASTROINTESTINAL AUTOIMMUNE DISEASES

 

57. Autoimmune Gastritis and Pernicious Anemia:

Ban-Hock Toh, MBBS, DSc

Autoimmunity Laboratory

Centre for Inflammatory Diseases

Department of Medicine

Southern Clinical School

Faculty of Medicine

Nursing and Health Services

Monash University

Clayton

Victoria

Australia

 

Senga Whittingham MBChB, PhD

Department of Biochemistry and Molecular Biology

Monash University

Australia

 

Frank Alderuccio, BSc hons, PhD

Department of Immunology

Monash University

Australia

 

58. Ulcerative Colitis:

Karsten Conrad, M.D.

Institute of Immunology

Medical Faculty of the Technical University Dresden

Dresden

Germany

 

Dr. Martin Laass, M.D.

Department of Pediatrics

Medical Faculty of the Technical University of Dresden

Dresden

Germany

 

59. Inflammatory Bowel Disease

Miquel Sans. MD, Ph.D.,

Department of Gastroenterology,

Hospital ClÉnic I Provincial / IDIBAPS

CIBER EHD

Barcelona, Spain

 

Carolina Figueroa, M.D.

Department of Gastroenterology,

Hospital ClÉnic I Provincial / IDIBAPS

CIBER EHD

Barcelona, Spain

 

60. Celiac Disease:

Nicola Bizzaro, M.D.

Laboratory of Clinical Pathology

Ospedale Civile

Tolmezzo, Italy

 

Elio Tonutti

Immunopatologia e Allergologia

Azienda Ospedaliero-Universitaria S. Maria della Misericordia

Udine

Italy

 

VIII. CUTANEOUS AUTOIMMUNE DISEASES

 

61. Cutaneous Lupus Erythematosus:

Annegret Kuhn

Department of Dermatology

University of Düesseldorf

Düesseldorf

Germany

 

Vincent Ruland

Department of Dermatology

University of Düesseldorf

Düesseldorf

Germany

 

Gisela Bonsmann

Department of Dermatology

University of Münster

Münster

Germany

 

62. Pemphigus and Bullous Pemphigoid:

Daniel Mimouni, MD

Dermatology Department

Rabin Medical Center

Beilinson Campus

Petah Tiqwa

Israel

Affiliated to Tel-Aviv University

Sackler Faculty of Medicine

Tel-Aviv Israel

 

Michael David, M.D.

Dermatology Department

Rabin Medical Center

Beilinson Campus

Petah Tiqwa

Israel

Affiliated to Tel-Aviv University

Sackler Faculty of Medicine

Tel-Aviv Israel

 

63. Vitiligo:

Sharon Baum, MD

Dermatology Department

Sheba Medical Center (Affiliated to the Sackler Faculty of Medicine)

Tel Aviv University

 

Aviv Barzilai, M.D.

Dermatology Department

Sheba Medical Center (Affiliated to the Sackler Faculty of Medicine)

Tel Aviv University

 

Henri Trau, M.D.

Dermatology Department

Sheba Medical Center (Affiliated to the Sackler Faculty of Medicine)

Tel Aviv University

 

64. Psoriatic Anthropathy:

Gleb Slobodin, MD

Dep. of Internal Medicine A

Bnai-Zion Medical Center

Technion Medical School

Haifa, Israel

 

Elias Toubi, M.D.

Director of Clinical Immunology and Allergy

Bnai-Zion Medical Center,

Technion Medical School

Haifa, Israel

 

IX. CARDIOVASCULAR AND PULMONARY AUTOIMMUNE DISEASES

 

65. Are Autoimmune Manifestation In Human Dilated Cardiomyopathy Primary Or Secondary Events?:

Lara E. Pereira, PhD

Department of Pathology and Laboratory Medicine

Emory University

Atlanta, Georgia

 

Aftab A. Ansari, PhD

Professor

Department of Pathology

Emory University School of Medicine

Atlanta, Georgia

 

66. Rheumatic Fever:

Yaniv Sherer, MD

Department of Medicine B

Center of Autoimmune Diseases

Sheba Medical Center

Tel-Hashomer

and

Sackler Faculty of Medicine

Tel-Aviv University

Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Head, Department of Medicine B

Center for Autoimmune Diseases

Sheba Medical Center

Tel-Hashomer

And Sackler Faculty of Medicine

Tel-Aviv University

Israel

and

Incumbent of the Laura Schwartz Kipp Chair

for Research of Autoimmune Diseases

Tel-Aviv University

Israel

67. Autoimmune Dilated Cardiomyopathy

U. Nussinovitch

Department of Medicine B

Chaim Sheba Medical Center

Tel-Hashomer, Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Incumbent of the Laura Schwarz-Kipp Chair for

Research of Autoimmune Diseases

Tel-Aviv University

Tel-Aviv

Israel

 

68. Accelerated Atherosclerosis in Autoimmune Diseases:

Nicoletta Ronda, M.D.

Department of Clinical Medicine

Nephrology and Health Science

University of Pharma

Italy

 

Pier Luigi Meroni, M.D.

Department of Internal Medicine

University of Milan and IRCCS Istituto Auxologico Italiano

Italy

 

69. Idiopathic Interstitial Pneumonias:

Antoni Xaubet, MD, PhD

Senior Consultant. Department of Respiratory Diseases

Hospital ClÉnic. Barcelona

Associate Professor of Medicine

University of Barcelona

Servei de Pneumologia

Hospital ClÉnic

Villarroel 170

Barcelona 08036 Spain

 

Maria Molina-Molina, M.D., PhD

Department de PatologÉa Experimental

Institut d'Investigacions Biomèdiques de Barcelona

Consejo Superior de Investgaciones CientÉficas

Institut d'Investigacions Biomèdiques August Pi I Sunyer

Barcelona

Spain

 

Anna Serrano-Mollar PhD

Departament de PatologÉa Experimental

Institut d'Investigaciones CientÉficas

Institut d'Investigaciones Biomèdiques August Pi I Sunyer

Barcelona

Spain

 

70. Pulmonary Arterial Hypertension:

Isabel Blanco

Servei de Pneumologia

Institut ClÉnic del Tórax

Hospital ClÉnic

Universitat de Barcelona

Barcelona

Spain

 

Joan-Albert Barberà, M.D.

Assistant Professor

Department of Medicin

University of Barcelona

Barcelona, Spain and

Senior Consultant

Department of Pulmonary Medicine

Thorax Institute

Hospital ClÉnic

Barcelona, Spain

 

X. NEUROLOGICAL AUTOIMMUNE DISEASES

 

71. Multiple Sclerosis:

Ron Milo, M.D.

Department of Neurology

Barzilai Medical Center

Ashkelon

Ben-Gurion University of Negev

Israel

 

Ariel Miller, M.D., PhD

Multiple Sclerosis and Brain Research Center

Rappaport Facilty of Medicine & Research Institute

Technion-Israel Institute of Technology

Department of Neurology

Carmel Medical Center

Haifa Israel

 

72. Myasthenia Gravis:

Alexander Gorshtein, M.D.

Department of Internal Medicine E

Meir Hospital

Kfar Saba 44281

Israel

 

Yair Levy, M.D.

Department of Internal Medicine E

Meir Hospital

Kfar Saba 44281

Israel

 

73. Autoantibodies In The Lambert-Eaton Myasthenic Syndrome:

Bethan Lang PhD

Neurosciences Group

Department of Clinical Neurology

Weatherall Institute of Molecular Medicine

John Radcliffe Hospital

Oxford University

Oxford

 

74. Autoanitbodies In Amyotrophic Lateral Sclerosis (ALS):

Bethan Lang PhD

Neurosciences Group

Department of Clinical Neurology

Weatherall Institute of Molecular Medicine

John Radcliffe Hospital

Oxford University

Oxford

 

75. Paraneoplastic Neurological Syndromes: Diagnosis and Treatment:

Tomeu Rossiñol, M.D.

Service of Neurology

Hospital Clinic

Universitat de Barcelona and

Institut d' Investigació Biomèdica August Pi i Sunyer (IDIBAPS)

Barcelona, Spain

 

Francesc Graus, M.D.

Service of Neurology

Hospital Clinic

Universitat de Barcelona and

Institut d' Investigació Biomèdica August Pi i Sunyer (IDIBAPS)

Barcelona, Spain

 

76. Gullain-Barré and other immune-mediated neuropathies:

Avraham Unterman, M.D.

Department of Medicine B

Center for Autoimmune Diseases

Chaim Sheba Medical Center

Tel-Hashomer

Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Head, Department of Medicine B

Center for Autoimmune Diseases

Chaim Sheba Medical Center

Tel-Hashomer

Israel

 

Joab Chapman, M.D., PhD

Department of Neurology

Sheba Medical Center and Sackler Faculty of Medicine

Tel Aviv University, Israel

 

77. Neuromylelitis optica (Devic's syndrome): Diagnosis and insights for demyelinating diseases and myelitis:

Joab Chapman

Department of Neurology

Sheba Medical Center and Sackler Faculty of Medicine

Tel Aviv University, Israel.

 

78. Central Nervous System Vasculitis:

Gisele Zandman-Goddard

Department of Medicine C

Wolfson Medical Center

Sackler Faculty of Medicine

Tel-Aviv University

Israel

 

Yehuda Shoenfeld, M.D., FRCP

Center for Autoimmune Diseases and

Department of Medicine B

Sheba Medical Center

Sackler Faculty of Medicine

Tel-Aviv University

Israel

And

Incumbant for the Laura Shwartz-Kipp Chair in Autoimmunity

Tel-Aviv University

Israel

 

79. Autoanitbodies In Epilepsy:

Sarosh R. Irani, BA, MRCP

Department of Clinical Neurology

University of Oxford

John Radcliffe Hospital

Oxford

 

Bethan Lang, PhD

Department of Clinical Neurology

University of Oxford

John Radcliffe Hospital

Oxford

 

80. The diagnosis of autoimmune Chorea:

Ziv Paz, MD, M. Sc

Department of Medicine 'B'

Center for Autoimmune Diseases

Chaim Sheba Medical Center

(Affiliated to Tel-Aviv University)

Tel-Hashomer

Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Head, Department of Medicine B

Center for Autoimmune Diseases

Chaim Sheba Medical Center

Tel-Hashomer

Israel

 

Joab Chapman, M.D., PhD

Department of Neurology

Sheba Medical Center and Sackler Faculty of Medicine

Tel Aviv University, Israel.

 

81. The Autoimmune Characteristics of Sensorineural Hearing Loss:

A. Kessel

Division of Clinical Immunology and Allergy

Bnai-Zion Medical Center

Affiliated with the Technion Faculty of Medicine

Haifa

Israel

 

Elias Toubi, M.D.

Director of Clinical Immunology and Allergy

Bnai-Zion Medical Center,

Technion Medical School

Haifa

Israel

 

XI. OCULAR AUTOIMMUNE DISEASES

 

82. Autoimmune Retinopathies:

Joan Giralt, M.D.

Institut Clinic d´Oftalmologia

Hospital Clinic i Provincial.Universidad de Barcelona

Barcelona

Spain

 

Alfredo Adan, M.D., PhD

Head, Department of Ophthalmology

Institut Clinic d´Oftalmologia

Hospital Clinic i Provincial.Universidad de Barcelona

Barcelona

Spain

 

83. Diagnostic Criteria for Autoimmune Diseases: Autoimmune Uveitis:

Francisco Assis de Andrade

Hospital do Olho and Centro Oftalmológico de Botafogo

Rio de Janeiro

Brasil

 

Ivan Foeldvari

Hamburger Zentrum fuer Kinder- and Jungerrheumatologie

Am Klinikum Eilbek Hamburg

Germany

 

Roger A. Levy

Diagnósticos da América SA and

Discipline of Rheumatology

Faculdade de Ciências Médicas

Universidade do Estado do Rio de Janeiro

Brasil

 

84. Vogt-Koyanagi-Harada Disease:

Jozélio Freire De Carvalho, MD, PhD

Assistant Professor

Faculdade de Medicina e Hospital das ClÉnicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo -SP

Brazil

 

Joyce Hisae Yamamoto, M.D., PhD

University of São Paulo

School of Medicine

São Paulo - SP

Brazil

 

85. Orbital Myositis:

Sergio Prieto, M.D.

Internal Medicine Department

Medicine and Dermatology Institute

Hospital ClÉnic de Barcelona

University of Barcelona

Barcelona, Catalonia, Spain

 

Josep M. Grau, MD, PhD

Senior Consultant

Department of Internal Medicine

Muscular Research Group

Hospital ClÉnic de Barcelona

Professor of Medicine

University of Barcelona

Barcelona, Catalonia, Spain

 

XII. RENAL AUTOIMMUNE DISEASES

 

86. IgA Nephropathy:

Jordi Ara i del Rey

Nephrology Department

Hospital Germans Trias

Badalona

Barcelona

 

87. Membranous Nephropathy:

Ziv Paz, MD, M. Sc

Department of Medicine 'B'

Center for Autoimmune Diseases

Chaim Sheba Medical Center

(Affiliated to Tel-Aviv University)

Tel-Hashomer

Israel

 

Yehuda Shoenfeld, M.D., FRCP (Hon.)

Head, Department of Medicine B

Center for Autoimmune Diseases

Chaim Sheba Medical Center

Tel-Hashomer

Israel

 

88. Minimal Change Nephropathy:

Pilar Arrizabalaga Clemente, M.D., PhD

Nephrology and Renal Transplant Service

Hospital Clinic

Biomedicial Investigation Institute August Pi I Sunyer

Barcelona

Spain

 

89. Focal and Segmental Glomerulosclerosis:

José A. BallarÉn, M.D., PhD

Head of Nephrology Service

Puigvert Foundation

Universidad Autonoma de Barcelona

Barcelona

Spain

 

Cristina Cabrera, M.D.

Nephrology Department

Puigvert Foundation

Universitat Autonoma de Barcelona

Barcelona

Spain

 

Carlos Quereda, M.D.

Nephrology Department

Hospital Ramón y Cajal

Madrid

Spain

 

Montserrat DÉaz, M.D.

Nephrology Department

Puigvert Foundation

Universitat Autónoma de Barcelona

Barcelona

Spain

 

90. Membranoproliferatice or Mesangiocapillary Glomulonephritis:

Montserrat M. DÉaz, MD

Nephrology Consultant

Clinical Nephrology Department

Puigvert Foundation

Universidad Autónoma de Barcelona

Barcelona

Spain

 

Laia Sans, M.D.

Nephrology Department

Puigvert Foundation

Universidad Autónoma de Barcelona

Barcelona

Spain

 

Yolanda Arce, M.D.

Nephrology Department

Puigvert Foundation

Universidad Autónoma de Barcelona

Barcelona

Spain

 

José Ballarin C., M.D., PhD

Nephrology Department

Puigvert Foundation

Universidad Autónoma de Barcelona

Barcelona

Spain

 

XIII. HEMATOLOGIC AUTOIMMUNE DISEASES

 

91. Autoimmune Hemolytic Anemia:

Urs E. Nydegger, M.D.

Consultant Octapharma Switzerland

Transfusion Therapy Consultancy TTC

Emeritus Medical Faculty University of Bern

Switzerland

 

92. Pernicious Anemia:

Mario Garcia-Carrasco, M.D., PhD

Systemic Autoimmune Diseases Research Unit

HGR #36

CMN Manuel Ávila Camacho

IMSS

Puebla

México

and

Rheumatology Department

Benemerita Universidad Autonoma de Puebla

School of Medicine

Puebla

México.

 

Mario Jiménez-Hernández, M.D.

Rheumatology Department

School of Medicine

Benemérita Universidad Autónoma de Puebla

Puebla

Mexico

 

Claudia Mendoza-Pinto, M.D.

Mario Garcia-Carrasco, M.D., PhD

Systemic Autoimmune Diseases Research Unit

HGR #36

CMN Manuel Ávila Camacho

IMSS

Puebla

México

 

Alejandro Ruiz-Argüelles, M.D.

Laboratorios ClÉnicos de Puebla

Puebla

Mexico

 

Salvador Fuentes-Alexandro, M.D.

Internal Medicine CMN siglo XXI

Instituto Mexicano del Seguro Social

DF

Mexico

 

93. Idiopatic Aplastic Anemia:

Baraf Lior, M.D.

Department of Medicine E

Meir Medical Center

Kfar-Saba

Affiliated to the Sackler Faculty of Medicine

Tel-Aviv University

Tel-Aviv

Israel

 

Levy Yair, M.D.

Department of Medicine E

Meir Medical Center

Kfar-Saba

Affiliated to the Sackler Faculty of Medicine

Tel-Aviv University

Tel-Aviv

Israel

 

94. Acquired Adult Pure Red Cell Aplasia:

Hedi Orbach, MD

Head of Internal Medicine B Department

Wolfson Medical Center

Holon

Israel

e-mail: hedi@md.huji.ac.il

 

Gisele Zandman Goddard

Department of Medicine C

Wolfson Medical Center

Holon

Israel

And

Sackler Faculty of Medicine

Tel-Aviv University

Israel

 

Asher Winder

Sackler Faculty of Medicine

Tel-Aviv University

Israel

And

Hematology Department

Wolfson Medical Center

Holon

Israel

 

Yehuda Shoenfeld, M.D.

Sackler Faculty of Medicine

Tel-Aviv University

Israel

And

Department of Medicine B

Chaim Sheba Medical Center

Tel-Hashomer

Israel

And

Incumbent of the Laura Schwarz-Kipp

Chair for Research of Autoimmune Diseases

Tel-Aviv University

Tel-Aviv Israel

 

95. Myelodysplastic Syndromes:

Laura F. Newell, M.D.

Department of Hematology

University of Washington

Seattle

Washington

 

Joseph M. Tuscano, M.D.

Associate Professor of Medicine

Department of Internal Medicine and

The UC Davis Cancer Center

Division of Hematology and Oncology

University of California

Davis School of Medicine

Sacramento

California

 

96. Autoimmune Lymphopenia:

Amani Mankai, PhD

Department of Immunopathology

Brest University Medical School

Brest

France

And

On leave from the Faculty of Pharmacy

Monastir

Tunisia

 

Sophie Hillion. PhD

Department of Immunopathology

Brest University Medical School

Brest

France

 

Valérie Devauchelle-Pensec, M.D., PhD

Department of Immunopathology

Brest University Medical School

Brest

France

 

Alain Saraux, M.D., PhD

Department of Immunopathology

Brest University Medical School

Brest

France

 

M. Eric Gershwin, M.D.

University of California at Davis

School of Medicine

Davis

California

 

Pierre Youinou, MD, DSc

Department of Immunopathology

Brest University Medical School

Brest

France

 

 

97. Autoimmune Neutropenia

Pierre Youinou, MD, DSc

Professor of Immunology

Brest University Medical School

Brest, France

 

Amani Mankai, PhD

Department of Immunopathology

Brest University Medical School

Brest

France

And

Laboratory of Immunology,

Faculty of Pharmacia

Monastir

Tunisia

 

Sophie Hillion, PhD

Department of Medicine B

Sheba Medical Center

Tel Hashomer

Israel

 

Yehuda Shoenfeld, M.D., FRCP

Department of Medicine B

Sheba Medical Center

Tel Hashomer

Israel

 

Christian Berthou, M.D., PhD

Department of Immunopathology

Brest University Medical School

Brest

France

 

Ibtissem Ghedira, PharmD, PhD

Laboratory of Immunology,

Faculty of Pharmacia

Monastir

Tunisia

 

98. Autoimmune Thrombocytopenic Purpura:

Nurit Rosenberg, PhD

Amalia Biron Research Institute of Thrombosis and Hemostasis

Sheba Medical Center

Tel-Hashomer

Israel

 

Yulia Einav, PhD

Mathematical Biology Unit

Faculti of Sciences

Holon Institute of Technology

Israel

 

Boris Shenkman, MD, PhD

Amalia Biron Research Institute of Thrombosis and Hemostasis

Sheba Medical Center

Tel-Hashomer

 

99. Thrombotic Thrombocytopenic Purpura and Other Thrombotic Microangiopathic Hemolytic Anemias:

Boris Shenkman, MD, PhD

Amalia Biron Research Institute of Thrombosis and Hemostasis

Sheba Medical Center

Tel-Hashomer

Israel

 

Yulia Einav, PhD

Mathematical Biology Unit

Faculti of Sciences

Holon Institute of Technology

Israel

 

Ophira Salomon, M.D.

Amalia Biron Research Institute of Thrombosis and Hemostasis

Sheba Medical Center

Tel-Hashomer

Israel

 

100. Heparin-Induced Thrombocytopenia:

Gowthami M. Arepally

Division of Hematology

Duke University Medical Center

Durham, North Carolina

 

Douglas B. Cines

Professor of Pathology &Laboratory Medicine

Vice Chair, Pathology & Laboratory Medicine

University of Pennsylvania School of Medicine

Philadelphia, Pennsylvania

 

101. Autoimmune Coagulopathies:

Fabio Tucci, M.D.

A. Meyer Children's Hospital

Firenze

Italy

 

Rolando Cimaz, M.D.

Rheumatology

Meyer Hospital

Firenze

Italy

 

102. Polymyalgia Rheumatica

Gideon Nesher, M.D.

Department of Internal Medicine A

And the Rheumatology Service

Shaare-Zedek Medical Center

Jerusalem

Israel

 

103. Clinically-Amyopathic Dermatomyositis

Richard D. Sontheimer, M.D.

Professor and Vice-Chairman, Department of Dermatology

Richard and Adeline Fleischaker Chair in Dermatology Research

University of Oklahoma Health Sciences Center

Adjunct Investigator

Oklahoma Medical Research Foundation

Oklahoma City

Oklahoma

 

Pedram Gerami, M.D.

Assistant Professor of Dermatology

Northwestern University Medical Center

Chicago

Illinois

 

Hobart W. Walling, M.D., PhD

Private Practice of Dermatology

Coralville

Iowa