Therapeutic Advances in Thrombosis 2/e

Managing patients with thrombotic vascular disease is complex and challenging:

Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis—even with the evolution in our understanding of the pathobiology of thrombosis.
There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents

Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject.

Written and edited by today’s leading international, Therapeutic Advances in Thrombosis, 2e provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get:

Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapies
Strategies to manage specific clinical conditions and how to tailor treatment to individual patient needs
Updated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunction
Special emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation.

Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn.

CONTENTS

1 Arterial Thrombosis: a brief overview
Lina Badimon and Valentin Fuster

2 Aspirin
Carlo Patrono

3 Part 1 Platelet ADP P2Y12 Inhibitors - Thienopyridines
Joseph D. Foley III, and David J. Moliterno

3 Part 2 Platelet ADP P2Y12 Inhibitors – Non-Thienopyridines
Joseph D. Foley III, and David J. Moliterno

4 Cilostazol and Dipyridamole- More than weak inhibition of platelets
W.G. Eisert

5 The Inter-relationship of Thrombin and Platelets—The Protease Activated Receptor-1 (PAR-1)
Matthew E. Wiisanen and David J. Moliterno

6 Glycoprotein IIb/IIIa inhibitors
Marco Valgimigli and Elisa Cangiano

7 Unfractionated heparin and low-molecular-weight heparin in ischemic heart disease
Marc Cohen, Omar Hassan and Zafar Iqbal

8 Pentasaccharide derivatives
Antonio Gutierrez, Pierluigi Tricoci and John H.P. Alexander

9 Intravenous direct thrombin inhibitors
A. Michael Lincoff

10 Vitamin K antagonists
Freek W.A. Verheugt

11 Oral direct thrombin inhibitors and oral Xa inhibitors
Steen Husted and Lars Wallentin

12 Thrombolytic therapy and concomitant antithrombotic therapies
Peter R Sinnaeve and Frans J Van de Werf

13 Antithrombotic therapy in STEMI
Kurt Huber, Raffaele De Caterina, Steen Kristensen

14 Antithrombotic Therapy in Non-ST Elevation Acute Coronary Syndromes
Georgios J. Vlachojannis , Vijayalakshmi Kunadian, Joseph M. Sweeny and Roxana Mehran

15 Antithrombotic strategies in patients undergoing elective PCI
Sunil V. Rao and E. Magnus Ohman

16 ANTITHROMBOTIC MANAGEMENT IN PATIENTSW ITH PROSTHETIC VALVES
Eric G Butchart and Raffaele De Caterina

17 Stroke – Thrombolysis and Antithrombotic Therapy
L. Creed Pettigrew and Michael R. Dobbs

18 Atrial fibrillation: current and forthcoming antithrombotic therapies
Raffaele De Caterina and Giulia Renda

19 Venous thromboembolism: pathophysiology, diagnosis and prophylaxis
M.P. Donadini, W. Ageno, A.G.G. Turpie

20 Antithrombotic therapy in venous thrombosis and pulmonary embolism
M. Di Nisio and H.R. Büller

21 PREVENTION AND TREATMENT OF VENOUS AND ARTERIAL THROMBOSIS IN PATIENTS WITH SPECIFIC CONDITIONS: DIABETES, HYPERCOAGULABLE STATES, PREGNANCY AND RENAL INSUFFICIENCY
Michel Meyer SAMAMA, Jacqueline CONARD and Grigoris GEROTZIAFAS

22 Genetics of the response to antithrombotic drugs and the need for monitoring
Jean-Philippe COLLET, Gilles MONTALESCOT and Jean-Sébastien HULOT