Immunology 8/e

Extensively updated, with new contributors, brilliant new illustrations and a wealth of supporting material online, this 8th edition offers you a carefully structured approach to learning the building blocks of the immune system as well as initiation and actions of the immune response. The website which accompanies this text gives access to all the images in the book, up to 20 detailed animation sequences (which link to further supporting text, illustrations, molecular models and video clips), 8 lectures which explain how the immune system responds to different infections or to tissue grafts, and a test bank of over 200 + multiple choice and 100 USMLE-style questions.

David Male, MA, PhD, Professor of Biology, Department of Life Sciences, The Open University, Milton Keynes, UK; Jonathan Brostoff, MA, DM, DSc(Med), FRCP, FRCPath, Professor Emeritus of Allergy and Environmental Health, King's College London, London, UK; David Roth, MD, PhD, Simon Flexner Professor and Chair of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA and Ivan Roitt, DSc HonFRCP FRCPath FRS, Hon Director, Middlesex Centre for Investigative & Diagnostic Oncology, School of Health & Social Sciences, Middlesex University, London, UK

Table of Contents:

1 Introduction to the immune system


Components of the Immune System


2 Cells, tissues and organs of the immune system

3 Antibodies

4 Complement

5 T cell receptors and MHC molecules


Modes of Immune Response


6 Mechanisms of innate immunity

7 Antigen presentation

8 The antibody response

9 Mononuclear phagocytes in immune defence

10 Cell mediated cytotoxicity

11 Regulation of the immune response

12 Immune responses in tissues


Defense Against Infectious Agents


13 Immunity to viruses

14 Immunity to bacteria and fungi

15 Immunity to protozoa and worms

16 Primary Immunodeficiency

17 AIDS and secondary immunodeficiency

18 Vaccination against infection


Immune Responses Against Tissues


19 Immunological tolerance

20 Autoimmune disease

21 Transplantation and rejection

22 Tumour immunotherapy


Hypersensitivity


23 Type I hypersensitivity

24 Type II and III hypersensitivity - basic science

25 Type II and III hypersensitivity - clinical

26 Type IV hypersensitivity